About the authorFreddie TaylorShare the loveHave your say Chelsea midfielder Mount feared long-term injuryby Freddie Taylora month agoSend to a friendShare the loveMason Mount has revealed he feared he had suffered a long-term injury against Valencia last week.The midfielder was substituted after 15 minutes during the 1-0 loss, but returned to start against Liverpool on Sunday.”As soon as I did it I thought it was going to be a long-term injury,” Mount said.”But then I iced it and it calmed down and I realised it was not as bad as I first thought. The next day I was jogging on it a little and from then I knew there was a chance of me being involved [against Liverpool yesterday].”There is still swelling there now but it is solid and I felt good and I trained the day before. I was pretty positive the day before the game that I would be involved.”He added: “You have to block the injury out of your mind and focus on the game.”When I had that chance which I felt I should have scored I rolled my ankle a little bit and it felt fine. It was fine throughout the whole game. It was solid.”Your Champions League debut, you don’t want it to end so soon, but that is football, it happened, and I try to stay positive. “I looked forward to the Liverpool game and set a goal that hopefully I could get ready for that. I feel like I am a quick recoverer and we worked on it hard and I was able to get back.”
About the authorFreddie TaylorShare the loveHave your say Arsenal boss Emery fumes over Sokratis penalty call: Where was VAR?by Freddie Taylor4 days agoSend to a friendShare the loveUnai Emery believes Arsenal were robbed of a clear penalty against Sheffield United on Monday night. The Blades won the match 1-0 thanks to a first-half strike from Lys Mousset.But Emery says the Gunners were unlucky not to have a chance to equalise from the penalty spot after Sokratis was fouled in the box.He told Sky Sports: “The scorer was with our goalkeeper and we had three players free to attack the ball. They gave us a key moment – the goal and another one when we should have had a clear penalty on Sokratis.”Bukayo Saka drives forward but I do not know if it was a penalty. It is a hard action for a yellow card. With VAR, the foul on Sokratis should have been reviewed. it was clear but we have to accept it.”
Prince Harry received a fantastic welcome when his tour of America began last week – and a glowing tribute from First Lady Michelle Obama.Hundreds of people greeted him on Washington’s Capitol Hill when he attended an event promoting the HALO Trust, an anti-landmine charity he supports.And when he was announced as a surprise guest at a White House tea reception honouring military mothers he received a standing ovation and more whoops of delight from US servicewomen and their children. He was a surprise guest whose attendance had been kept secret from the 170 invited mothers, grandmothers and youngsters.Mrs Obama and Dr Jill Biden, the wife of Vice President Joe Biden, hosted the White House event in honour of military mothers.It was part of their Joining Forces project, a nationwide initiative launched in 2011 to encourage Americans to support and provide opportunities for the military and their families.Before Prince Harry was introduced to the military mothers he had joined their children who were making Mother’s Day goody bags in the White House’s state dining, filling them with bouquets of roses, edible salted dough jewellery and baked crisps.With Mother’s Day traditionally held on the second Sunday of May in America, the children were busy at work. But The Prince soon joined in bending down to talk to the children and pulling faces and joking with the youngsters.At one point Mrs Obama joked that the parents were getting “a couple of minutes of free babysitting”.Earlier in the day Prince Harry was given a deafening welcome when he arrived at the Russell Senate Office building on Capitol Hill for a photographic exhibition highlighting the work of the Halo Trust.He was joined by former presidential candidate Senator John McCain who stepped in as a replacement for his wife Cindy, a leading US anti-landmine campaigner, after she was taken ill.The Prince has followed in the footsteps of his mother Diana, Princess of Wales by supporting the Halo Trust, founded in 1988, and this year the became Patron of its 25th anniversary appeal.Prince Harry also visited Africa to promote the charity’s work travelling to Mozambique in 2010 where, under supervision, he detonated several mines and met people who had lost limbs to landmines.Mr McCain, a former fighter pilot who was held hostage after being shot down in Vietnam, said: “He knew I had been shot down and I told him he was probably a much better pilot than me because he hadn’t been shot down.”The tour will also take The Prince to New York where he will support the Great Campaign, a government initiative which promotes the UK around the world on the back of the success of the Diamond Jubilee and London 2012.Prince Harry will also attend a baseball event in the Big Apple as he promotes a sports programme involving his Royal Foundation. On the final day Prince Harry will play in the Sentebale Polo Cup in aid of his Africa-based charity.Source:PrinceHenryOfWales.org
The Toronto Stock Exchange’s main index slipped slightly lower Monday, while markets south of the border inched forward after seeing some losses earlier in the day.The S&P/TSX composite index shed 13 points to 16,026.26.The indice’s performance is tied to geopolitical tensions, said Kash Pashootan, CEO and chief investment officer at First Avenue Investment Counsel.Ongoing trouble between the U.S. and North Korea, as well as other global political issues have led to concerns about an oil supply disruption, he said, driving the commodity price higher and creating a resource-rooted rally for the exchange.However, the price of oil didn’t move much Monday — with the December crude contract gaining two cents to US$56.76 per barrel — leaving the TSX relatively flat as well, Pashootan said.On Wall Street, indices continued to question whether U.S. President Donald Trump will deliver on promised reforms, like a corporate tax cut, Pashootan said, and indices dipped into the red.“But there’s no question that the underlying enthusiasm and appetite for buying equities continues to remain strong,” he said, adding that’s what lifted indices before markets closed.The Dow Jones industrial average gained 17.49 points to 23,439.70, the S&P 500 index rose 2.54 points to 2,584.84 and the Nasdaq composite index advanced 6.66 points to 6,757.60.Pashootan expects U.S. markets to show volatility over the next couple of quarters, moving higher when optimism about Trump’s reform grows and retreating at any sign of challenges in the president’s way.Elsewhere in commodities, the December gold contract rose US$4.70 to US$1,278.90 an ounce and the December copper contract advanced roughly four cents to about US$3.12 a pound. The December natural gas contract fell about five cents to roughly US$3.17 per mmBTU.The Bank of Canada, which publishes the daily average exchange rate of the Canadian dollar, is closed in lieu of Remembrance Day.By Aleksandra Sagan in Vancouver.Follow @AleksSagan on Twitter.
By Abdelatif Ait AaziCasablanca- In a video that went viral on social media, a female university student who can be described as having long blond hair, wearing black pants and a pink sweater, was aggressively harassed both verbally and physically by a group of male colleagues who were shown trying to strip her clothes off her. The woman took refuge in the bathroom from the dozens of male students who were grabbing her until university security escorted her from the campus. But instead of condemning the behavior of students who harassed the young woman, the head of the Cairo University put the blame on her, arguing that she made a “mistake” when she dressed in an “unusual or inappropriate way” on campusSpeaking to the Egyptian private channel ONTV on Monday, the head of Cairo University, Gaber Nasser, said that “this girl entered the university wearing an abaya (loose cloak) and then took it off in the university “The girl’s mistake doesn’t justify [the male students’] behavior,” said Nasser, adding that the university does not allow students to wear “unusual or inappropriate” outfits on campus.“We will find out who is guilty – whether the girl or the [other] students – and we are going to punish them with the proper punishment, which might be expulsion from the university,” he was quoted by the The Guardian as sayingThe head of Cairo University added that the whole incident was monitored by security cameras and the harassers will be investigated.Egyptian women report that they encounter harassment even if they dress conservatively.According to a study conducted in 2013 by UN Women, more than 99% of women in Egypt have been subjected to a form of harassment.Edited by Sahar Kian© Morocco World News. All Rights Reserved. This material may not be published, rewritten or redistributed
Queenstown is giving away 300 hotel nights in September and October as operators encourage visitors to the Rugby World Cup (RWC 2011) to also attach a side trip to Queenstown.Although the city will not be hosting any games, Destination Queenstown is running a week-long spring sweepstake to give potential visitors the chance to win 300 free hotel room nights. Destination Queenstown chief executive Tony Everitt said the promotion is a good opportunity for international visitors to ‘bag a bonus’ for their big trip and relax in Queenstown during Spring whilst New Zealanders will can enjoy a great value getaway.“We’re aware that some people might be putting off a trip because they think accommodation may be expensive or hard to find. In fact here in Queenstown there’s still very good availability in our hotels and across all accommodation types and price ranges, from budget to five-star, during September and October,” Mr Everitt said. Destination Queenstown encourages anyone from around the world to enter the sweepstake which will open on the 01 August until the 08 August 2011, all accommodation prizes are being contributed by 19 local members of the New Zealand Hotel Council.Each winner will receive two consecutive nights for two people at their respective hotel, therefore 150 lucky winners and their partner will have the opportunity to experience Queenstown’s warm hospitality.Full details on the spring sweepstake are available on the Destination Queenstown website and Air New Zealand’s Twitter followers and Facebook pages. Queenstown Source = e-Travel Blackboard: S.P
Netflix and Canada’s documentary festival and conference, Hot Docs, are unveiling a five-year funding and development initiative for Canadian filmmakers.The Hot Docs ‘Canadian Storytellers Project’ will invest in funding and professional development programs for Canadian documentarians who may be indigenous, French-speaking, deaf and/or have a disability, or that are persons of colour.This will include the support of ten fellowships annually for Hot Docs’ Doc Accelerator program for emerging filmmakers. A handful of emerging filmmakers are already being supported via the program with support from Netflix at this year’s Hot Docs.In addition, the’ CrossCurrents Canada Doc Fund’ will financially support 25-40 independent doc projects from emerging filmmakers over the next five years with grants ranging from C$10,000 – $50,000 (£5,000-28,000).The Doc Fund will accept applications for its first round of funding this autumn.The news arrives after Netflix made a C$500m originals deal with the Canadian government to invest in original English and French-language programming over the next five years.“Netflix and its members around the world are passionate about documentary films and series,” said Netflix vice president of original docs and comedy Lisa Nishimura.“We are thrilled to partner with Hot Docs to support Canadian storytellers. This project will promote opportunities for emerging filmmakers, who offer a diversity of perspectives and connect their unique voices to global audiences.”
Dear Reader, Two weeks ago, gold dropped almost back to where it was last December. The resulting negative sentiment gripping the precious metals market and indeed the whole metals and mining sector is profound and far reaching—as bad as last December, or worse. Which is odd, because the better stocks have not returned to their December lows. Producers have cut costs, explorers and developers with quality assets have been able to raise the money needed to advance, and we’ve actually been able to book some profits this year. But that’s typical; markets tend to overreact, and that, of course, creates opportunities. That said, the Casey consensus is now that broader markets are set for a major correction—much greater than the 1,000 point slide the Dow has seen over the last month. We may at long last be on the verge of leaving the eye of the global economic storm, as we’ve called it. Our colleagues at The Casey Report are preparing a special report on this subject, which we will send to all paying subscribers. But whether or not a “waterfall event” is about to hit Wall Street and beyond, if we’re facing the possibility of another 2008-type downturn, it’s only prudent to rig for stormy weather. What does that mean? It means rebalancing more toward cash and culling underperformers to that end—especially companies low on funds or losing money. Being contrarians, however, we also want to prepare to go bargain hunting. It’s in this context that I want to share some price-to-book-value research we’ve done, as you’ll see below. It’s important to keep the difference between price and value in mind when the two diverge. And they already have. Things could start moving very quickly in the weeks ahead. We’ll do our best to keep you appraised and advise you on how to proceed. Subscribers should check our portfolio pages frequently this month. Before we get to today’s article, however, I’m pleased to announce our new documentary-style film on the only way for Americans to legally minimize their taxes without leaving the US. It’s called America’s Tax-Free Zone, and you can watch it for free. As I’m sure longtime readers can guess, the focus is on Puerto Rico’s new tax incentives. Doug Casey, Peter Schiff, and other experts walk viewers through the facts and what to do. I hope you enjoy the video; I’d love to have more of you become my neighbors here in the US Caribbean. Now, on to the main event. More next week, Sincerely, Copper 3.01 3.14 3.30 Rock & Stock Stats Last One Month Ago Gold Producers (GDX) 20.69 23.43 24.50 Gold 1,238.29 1,234.90 1,323.00 Gold Junior Stocks (GDXJ) 32.47 37.60 37.38 One Year Ago Silver 17.27 18.66 21.95 Louis James Senior Metals Investment Strategist Casey Research Gold (SGE) 1,243.72 1,249.15 1,302.08 TSX (Toronto Stock Exchange) 14,227.68 15,458.88 13,036.36 Silver Stocks (SIL) 10.39 11.98 12.80 TSX Venture 810.13 972.51 951.58 Oil 82.92 93.20 100.87
Updated at 9:05 a.m. ET Rear Adm. Ronny Jackson, President Trump’s embattled nominee to lead the Department of Veterans Affairs, has withdrawn from consideration for the post amid allegations he had fostered a hostile work environment and behaved improperly while serving as the top doctor leading the White House medical unit.In a statement Thursday morning, Jackson said, “Going into this process, I expected tough questions about how to best care for our veterans, but I did not expect to have to dignify baseless and anonymous attacks on my character and integrity.” He continued, “While I will forever be grateful for the trust and confidence President Trump has placed in me by giving me this opportunity, I am regretfully withdrawing my nomination to be Secretary for the Department of Veterans Affairs.” On Wednesday, Sen. Jon Tester, D-Mont., the ranking member of the Senate Veterans’ Affairs Committee released a two-page statement detailing allegations against Jackson from 23 unnamed individuals.The allegations included providing “a large supply” of the opioid Percocet to a member of the White House Military Office and wrecking a government car while driving drunk after a Secret Service going-away party. Jackson denied wrecking a vehicle to reporters. In an interview with Fox & Friends on Thursday after Jackson’s withdrawal, Trump said Jackson “would have done a great job” and “had a perfect record” and called the allegations against him false.The Senate Veterans’ Affairs Committee had postponed Jackson’s confirmation hearing, originally slated for Wednesday, after accusations of misconduct surfaced against Jackson, who has served as the personal physician for the president under the Trump and Obama administrations.In an interview Tuesday with NPR’s All Things Considered, Tester said committee staffers “were told stories where he was repeatedly drunk while on duty where his main job was to take care of the most powerful man in the world. That’s not acceptable,” Tester said, noting the various allegations date back to when Jackson oversaw President Barack Obama’s health care.”Some of the exact words that were used by the folks we talked to were ‘abusive toward staff,’ ‘very explosive personality,’ ‘belittles the folks underneath him,’ staff that he oversaw. ‘Screamed toward staff,’ ” Tester said. “Basically creating an environment where the staff felt that they needed to walk on eggshells when they were around him.”In the Fox interview, Trump blamed Tester for Jackson’s withdrawal and said Tester “has to have a big price to pay in Montana.” Tester is up for re-election in November, in a state Trump won handily in 2016.Trump says he has someone in mind to replace Jackson, saying it’s “somebody with political capability.”Veterans’ Affairs Committee Chairman Johnny Isakson, R-Ga., and Tester had sent a letter to Trump on Tuesday requesting additional documentation related to Jackson’s tenure as the president’s doctor and his role leading the White House medical team.The letter requested information about rumored Pentagon inspector general reports said to detail allegations into Jackson’s conduct.However, Jackson said there was no inspector general report about the allegations. “No, there was not,” he said before brushing off questions about whether he would withdraw.The White House put out a statement to make it clear that Jackson was reporting to work on Thursday in his normal post at the White House Medical Unit. But the questions about his conduct in that position may not necessarily go away just because he has withdrawn his name for the Cabinet post. Jackson’s initial nomination came as a surprise to many when the president announced his pick last month to lead the VA after the departure of Veterans Affairs Secretary David Shulkin, who had been confirmed with unanimous bipartisan support in the Senate.While previous presidents had praised Jackson’s medical care, questions arose almost immediately about whether he had the managerial experience to oversee a massive health care operation of more than 370,000 employees that serves more than 9 million veterans and has a budget of nearly $200 billion.”Adm. Jackson is highly trained and qualified and as a service member himself, he has seen firsthand the tremendous sacrifice our veterans make and has a deep appreciation for the debt our great country owes them,” Trump said in announcing his nomination.But after the allegations against Jackson began to be reported by national media outlets this week, Trump said he wouldn’t be surprised if Jackson wanted to withdraw given the rising storm, but that it was “his decision.””I wouldn’t do it. I wouldn’t do it. What does he need it for? To be abused by a bunch of politicians that aren’t thinking nicely about our country? I really don’t think personally he should do it, but it’s totally his — I would stand behind him — totally his decision,” Trump remarked Tuesday during a news conference alongside French President Emmanuel Macron.Ultimately, as he often does, Trump appeared to go with his gut in picking Jackson and it’s unclear how much — if any — vetting the White House did before making the selection. Trump had become personally fond of Jackson, especially after he gave the president a glowing review after his first presidential physical earlier this year, even boasting that the 71-year-old president had such “great genes” that “if he had a healthier diet over the last 20 years, he might live to be 200.”Jackson joined the White House medical unit in 2006, helping care for President George W. Bush, and was formally named physician to the president in 2013 by Obama. A West Texas native, he attended Texas A&M University and the University of Texas Medical Branch, specializing in emergency medicine.There were also questions about Jackson’s position on privatizing the VA — something many of Trump’s most conservative backers have pushed for. Shulkin said he believed that was one reason he was ousted from his post, though there were also questions raised about improper travel expenses during his tenure. Copyright 2018 NPR. To see more, visit http://www.npr.org/.
LivePerson Releases World’s First Collaborative AI Technology, Empowering All Staff in an Enterprise to Assist Technologists with Bot Building PRNewswireApril 30, 2019, 5:46 pmApril 30, 2019 Launch Customers, Including Fortune 500 Telecommunications, Marketing and Travel Companies, Have Used the New Conversation Builder to Train Nontechnical Staff and Create Customer-Facing Bots in as Little as 24 HoursLivePerson, a leading provider of conversational commerce solutions, announced the general availability (GA) of its new Conversation Builder technology, the world’s first all-in-one platform for building enterprise-scale chatbots. Conversation Builder is a dramatically faster way for brands to create conversational AI. With an entire toolkit to test, deploy, and improve chatbots in one closed-loop platform and allowing nontechnical users to assist in the development, Conversation Builder slashes the build time from a typical six weeks to as little as one day.The software general availability follows a successful early adopter program, in which leading enterprise companies saw spectacular results, including milestones such as:An onboarding where 30 contact center staff were successfully trained to build chatbots in a single sessionA one-day project to concept, build, test and deploy a bot for customers, which was ready that same dayIntegration into multiple messaging platforms — the “build once, run many” approach that multiplies the value of enterprise automations running on LivePersonWith brands under increasing pressure to provide great service and AI engineers hard to hire, Conversation Builder taps into an underutilized resource — the contact center staff who sell to and service customers all day — and empowers them to assist the technical team in building and improving chatbots. By encapsulating their extensive knowledge in the AI, brands can offer higher quality support — AI trained by personal, local and onshore experts — and avoid the false economy of low-cost offshoring that frustrates many customers.Marketing Technology News: New Study Finds the Current State of Pay TV, OTT & SVOD in 2019Alex Spinelli, CTO at LivePerson, adds, “This is an important step in our mission to transform the way brands and consumers connect to each other. Conversation Builder delivers the closed-loop process and nontechnical accessibility that brands need to scale up their conversational commerce. At LivePerson, we’re empowering the world’s largest brands to deliver messaging — powered by an intelligent mix of automation and humans — to billions of consumers.”The general availability of Conversation Builder puts in place a key component of LivePerson’s Maven AI engine, which has been engineered from the ground up to deliver the comprehensive range of capabilities that brands need to deploy conversational commerce at a massive scale. Conversation Builder introduces two critically important innovations:The first “closed loop” for enterprise bot building and deployment: a fully integrated, end-to-end system to build, run, and optimize bots, which slashes the time needed from multiple weeks to less than one day.A “no coding needed” approach that empowers nontechnical staff: millions of care agents in contact centers worldwide can build enterprise automations, instead of small in-house teams of AI specialists that are often overwhelmed and inadvertently bottleneck the process today.These two advances in AI creation solve a pressing challenge as conversational commerce becomes ubiquitous. Conversation Builder enables large brands to transform their chatbots from smaller-scale experiments to a robust production infrastructure that can accurately answer millions of consumer messages on a wide range of topics.Before today, the AI loop was extremely slow and fragmented with multiple separate human teams — AI specialists, engineers, operations and customer care — using multiple tools with awkward handoffs between them. The unwieldy process meant that each optimization opportunity to improve the chatbot could take upward of a month’s time from start to finish. Conversation Builder brings all this into one platform with impactful results: a one-day build time and optimization loops measured in hours instead of weeks.Marketing Technology News: STOMP Out Bullying™ Launches Emma, the First AI Platform Designed to Process and Respond to CyberbullyingLivePerson’s comprehensive system also includes natural language understanding (NLU), giving brands a single place to build enterprise automations from the ground up. For brands that have existing investments in conversational interfaces, Conversation Builder is an open platform and NLU-agnostic so it can import those intents and flows. Companies can then leverage that work and maximize the ROI of those projects, while building further on it with Conversation Builder’s one-stop, closed-loop environment, and the ability for nontechnical staff to make rapid improvements at scale.To further increase ROI, Conversation Builder automations can run across the widest range of consumer messaging endpoints, thanks to deep integration with LiveEngage, including SMS, web, in-app and the major messaging apps from Google, Facebook and LINE. It also includes out-of-the-box enterprise integrations to common platforms such as Shopify and Salesforce CRM, as well as prebuilt automations for a variety of vertical industries, which further accelerate the already short time it takes to deploy.Conversation Builder caters to the various enterprise AI stakeholders — IT, operations, care, marketing and sales — via user personas, which allow the right access level and appropriate user interfaces to do their work, including building, testing, visualization, intent creation and dialog creation. This allows brands to bring great conversational design discipline into the AI-building process as engineers and nonengineers can simultaneously work side by side in one system.This is tremendously faster than the old approach, which was plagued by awkward handoffs and major bottlenecks.A key part of the impact of Conversation Builder — the ability for a large group of contact center staff to learn it and get results in literally a single day — is due to its carefully designed, user-friendly interface. LivePerson used its unrivaled understanding of enterprise conversational commerce and real-life agent workflows to make the user experience for agents intuitive, familiar and quick to learn.Marketing Technology News: GroundTruth Names Chris Yamaoka Chief Privacy OfficerLivePerson’s conversational commerce solutions are uniquely flexible, with a comprehensive set of over 40 APIs and the ability for brands to choose from ready-built automations and NLUs or AI built elsewhere. LivePerson Conversation Builder is generally available, worldwide, today AIAlex SpinelliConversation Builder technologyLivepersonMarketing Technology NewsNewsSalesforce CRM Previous ArticleSAS Features Innovations in Automated Machine Learning, Computer Vision and NLP to Improve Decision MakingNext ArticleeSentire Report: Volume of UK Cyber Attacks Increased by Over 140 Percent in 2018
“The emerging personalized medicine field holds great potential for the application of NEC’s core technology, and we are pleased to be working with Transgene with the goal of developing state-of-the-art personalized immunotherapies,” said Motoo Nishihara, Senior Vice President, Head of NEC Laboratories.”Engaging the body’s own immune system in the fight against cancer has shown great promise and sparked unprecedented interest among oncology drug makers. This makes it imperative for NEC to become part of the immunotherapy race as soon as possible,” said Osamu Fujikawa, Senior Vice President, Business Innovation Unit, NEC Corporation.”This collaboration brings together artificial intelligence and our expertise in viral vector engineering to enable the development of a truly innovative treatment based on the myvac™ platform. We believe that our collaboration with NEC will allow us to provide an efficacious and robust therapy for the many patients who have solid tumors and could benefit from this cutting-edge individualized approach, and to successfully advance the development of the myvac™ platform to the market” said éric Quéméneur, Pharm.D., Ph.D., Executive VP, Chief Scientific Officer of Transgene. Source:https://www.nec.com/en/press/201810/global_20181030_02.html NEC’s cutting-edge AI technology, “NEC the WISE”, for identifying and prioritizing patient-specific neoantigens, and Transgene’s unrivaled MVA-based, viral vector technology and the myvac™ platform. Reviewed by James Ives, M.Psych. (Editor)Oct 30 2018NEC Corporation (NEC) and Transgene today announced the signing of a Memorandum of Understanding (MOU) for a strategic collaboration aimed at the treatment of solid cancers. The companies will cooperate in clinically assessing the predictive capabilities of NEC’s artificial intelligence (AI) and the therapeutic potential of Transgene’s myvac™ MVA-based viral vector platform in an individualized immunotherapy for the treatment of solid cancers. The experimental products from this collaboration are expected to enter clinical trials in 2019.NEC and Transgene will co-invest in the first stage of development of an individualized immunotherapy, which includes clinical trials focusing on ovarian cancer and HPV-negative head and neck cancer.Immunotherapy is rapidly becoming the treatment of choice to fight cancer as it activates the patient’s own immune system to attack cancer cells.NEC and Transgene have capitalized on the recent progress in AI and advances in genome sequencing to create individualized immunotherapy, which is adapted to the unique characteristics of each patient’s mutational landscape as well as their predicted immune responses. The product is based on a viral vector (MVA) developed by Transgene with a proven clinical safety track record and is known for its efficient immunogenicity and anti-tumor efficacy in patients.The viral vector will be used to target neoantigens identified using NEC’s proprietary algorithm. NEC has been developing solutions in the drug discovery field for close to two decades. NEC’s neoantigen prediction system was developed and validated based on publicly available databases, as well as internal wet lab datasets, some of which were already used to identify clinically relevant antigens in other oncology indications.Related StoriesUsing machine learning algorithm to accurately diagnose breast cancerTrends in colonoscopy rates not aligned with increase in early onset colorectal cancerStudy: Nearly a quarter of low-risk thyroid cancer patients receive more treatment than necessaryThese planned clinical trials leverage the world-leading expertise and technologies of a network of companies and research centers, including:
Reviewed by Kate Anderton, B.Sc. (Editor)May 3 2019All the surface of the human body is represented in the cerebral cortex in a transversal band localized at the external part of the cerebral hemispheres: the somatosensory cortex. Each body region occupies in that band a distinct extension depending on its use and sensitivity. For instance, the hands and the lips, on which humans rely most, occupy the largest area. Thus, the 3D representation of that map forms the known sensory homunculus.Similar to a cartographic map, each represented region of the body in the somatosensory cortex is connected to its corresponding body surface thanks to the neuronal pathways that keep a strict topographical relationship along the nervous system. In this pathway, the thalamus, a deep structure of the brain that lies beneath the cortices, plays a key role by relaying the peripheral information to the cortex without losing the point-to-point correspondence. Using this extraordinary precision, we can discriminate which point of our body is receiving an external stimulus and have a well-defined map of the periphery. Such accurate topography constitutes the basis of the sense of touch and is essential for survival of the species.How are the neurons of the somatosensory cortex organized during development to perform these functions? Neurons of this brain region, as in the rest of the cerebral cortex, are assembled into columns that are placed next to each other like building bricks. It remains unknown, however, how these columnar structures become functional correspondents of the distant regions of the periphery. Although some studies highlight the role of genetic factors to form initial columns, most studies in the past decade have emphasized that this disposition is achieved as a result of sensory experience during postnatal life.Now a study by the UMH-CSIC Institute of Neuroscience in Alicante published in Science shows that cortical columns are already defined and fully functional before birth thanks to the spontaneous electrical activity of the embryonic thalamus. Far from being a mere relay station, the thalamus guides the formation of the functional cortical columns and the concomitant somatotopic map in the still immature cortex, before external sensory experience is an effective source of information. In particular, the thalamus does so by generating and transmitting patterns of spontaneous activity (called waves) to the developing cortex. The discovery was made in rodents, in a particular and extensive region of their somatosensory cortex: the barrel cortex. This area contains the representation of the whiskers of the snout that are, for rodents, sensorially equivalent to our hands.Related StoriesNeural pathways explain the relationship between imagination and willingness to helpNew therapy shows promise in preventing brain damage after traumatic brain injuryAn active brain and body associated with reduced risk of dementia”Our data reveal that the embryonic patterns of electrical activity of the thalamus, the brain structure through which sensory information passes to the cortex, organize the architecture of the cortical somatosensory map. The development of this map involves the emergence of functional cortical columns in embryos, driven by activity in the form of waves that spontaneously propagate through the thalamus”, “We propose that this pattern of activity that takes place during the embryonic stages prepares the cortical areas and circuits for receiving information from the senses after birth”, explains CSIC researcher Guillermina López-Bendito.The researchers point out that since thalamic waves are not unique to the structure of the thalamus involved in the sense of touch but spread to other senses, such as vision or hearing, the cortical mapping principles described in this paper are likely shared by other sensory modalities.”It is very probable that this mechanism involved in the formation of the sensory maps that we have discovered in rodents can be extrapolated to humans, because the organization of the cortex is evolutionarily conserved between species”, explains López-Bendito.”The spontaneous activity of the thalamus is not something circumstantial, but contains important information for the construction of the brain during embryonic development. It was previously thought that neuronal circuits were built on a genetic imprint and that the postnatal sensory experience ends up defining the maps. This work questions this vision because it demonstrates the existence of these maps before birth,”; says Lopez-Bendito. “Our results indicate that the spontaneous thalamic activity during the embryonic phase is essential for the normal development of the brain, defining what in neurobiology is called a critical period, i.e. a period of time in which plastic changes are possible but after which alterations would be irreparable”; she adds.In addition to highlighting a novel mechanism for regulating brain development, such as the pattern of intrinsic embryonic activity in a subcortical structure, this work may have long-term repercussions in the understanding of certain pathologies. For example, in some disorders of neural development, such as autism or fragile X syndrome, in which alterations in the cortical structure are associated with sensory processing alterations.Source: http://www.csic.es/
Next India Today Web Desk New DelhiJuly 13, 2019UPDATED: July 13, 2019 21:37 IST Water has reached near the feet of the statue of Lord Vishnu. (Photo: ANI)A statue of Vishnu sitting on Sheshnag seems to be in danger. The statue is placed on a vertical pillar in the Brahmaputra river. The statue seemed to be on the verge of drowning as the water level crossed the danger mark following rainfall in the region. In a picture, the water is seen to have reached the feet of the statue on the pillar in the river near Chakreshwar temple in Kalipur.The impact of an increase in the water level of the Brahmaputra river was also seen in Morigaon district in Assam. In Tengaguri area of Morigaon, a building of a primary school collapsed due to the rising water level in the Brahmaputra river. The incident was captured on camera.The flood situation in Assam continued to worsen as new areas flooded on Saturday. The Assam State Disaster Management Authority (ASDMA) has said that 25 districts of the state are under water. One person died in a flood-related incident in Dhemaji in the last 24 hours taking the death toll to seven due to floods and landslides.According to the ASDMA, a total of 1,405,711 people have been affected by the deluge in 25 districts. “Over 20,000 people are living in 234 relief camps opened by the district administration,” an official of the ASDMA said on Saturday while adding that 51,722 hectares of agricultural land have also been submerged so far affecting the farmers.The affected districts include Dhemaji, Lakhimpur, Barpeta, Morigaon, Biswanath, Sonitpur, Darrang, Goalpara, Nagaon, Golaghat, Jorhat, Sivasagar, Dibrugarh and Tinsukia, the ASDMA said.The flood situation in Dhemaji and Lakhimpur remained the worst where most of the people have been affected. Several houses, roads and bridges have also been damaged after the breach of embankments that have led to flooding in many areas.The water level in Kaziranga National Park, spread over the floodplains of the Brahmaputra river, also increased following incessant rains. Sailen Pande, PRO of Assam Forest and Environment Minister, said, “This year, Ministry of Forest and Environment, Assam had taken precautions to deal with the flood.””Over 70 per cent of the park has been submerged with flood waters. All staffs have been put on alert to deal with the flood,” Sailen Pande said.Barpeta is the worst hit with 5.22 lakh people affected, followed by 1.38 lakh in Dhemaji and 95,000 in Morigaon, ASDMA said.Also Read | Bihar fears floods as heavy rains swell riversAlso Read | 2 dead, 390 houses submerged in Mizoram floodAlso Watch | In Depth: Decoding the link between floods and droughtsFor the latest World Cup news, live scores and fixtures for World Cup 2019, log on to indiatoday.in/sports. Like us on Facebook or follow us on Twitter for World Cup news, scores and updates.Get real-time alerts and all the news on your phone with the all-new India Today app. Download from Post your comment Do You Like This Story? Awesome! Now share the story Too bad. Tell us what you didn’t like in the comments Posted byChanchal Chauhan Assam floods: Sheshnag in trouble as Brahmaputra water hisses over danger mark in GuwahatiThe statue seemed to be on the verge of drowning as the water level crossed the danger mark following rainfall in the region.advertisement