first_imgA leading locksmith has warned that people need to update their locks and security systems.Statistics released show that there have been 461 burglaries across Donegal over the past twelve months.Conal Kelly of CK Locksmiths in Letterkenny says previous ways of warding or thieves no longer work. “Sadly, the days of leaving a hallway light on as an effective deterrent for thieves are gone,” he cautions.Conal says that there are a number of cost-effective and simple steps a home owner can take to reduce the risk of a break-in, including fitting good quality door and window locks or installing a secure safe to protect cash and other valuables kept at home.“Burglars are opportunistic. Many properties have weak door locks and poor security precautions. When an opportunistic burglar comes across an insecure property, someone’s going to have a bad day,” he says. The cost can often run to thousands of euro, while the impact on victims’ lives can be much worse.CK Locksmiths can be contacted on 074 91 22094.  DONEGAL LOCKSMITH WARNS OLD DETERRENTS NO LONGER WORK was last modified: January 29th, 2012 by StephenShare this:Click to share on Facebook (Opens in new window)Click to share on Twitter (Opens in new window)Click to share on LinkedIn (Opens in new window)Click to share on Reddit (Opens in new window)Click to share on Pocket (Opens in new window)Click to share on Telegram (Opens in new window)Click to share on WhatsApp (Opens in new window)Click to share on Skype (Opens in new window)Click to print (Opens in new window) Tags:burglaryCK Locksmithlast_img read more

Revealed! Every Premier League club ranked by net spend this transfer window

first_img 10. Brighton – Net spend: £9m (spent: £9m, received: £0m) 20 20 5. Huddersfield – Net spend: £36.4m (spent: £36.4m, received: £0m) 18. Tottenham – Net spend: -£16m (spent: £0m, received: £16m) 20 20 20 20 1. Manchester United – Net spend: £105.8m (spent: £105.8m, received: £0m) 20 20 15. Stoke City – Net spend: -£2m (spent: £0m, received: £2m) 8. West Brom – Net spend: £19.8m (spent: £19.8m, received: £0m) 20 20. Chelsea – Net spend so far (correct on 10 July 2017): -£34.5m (spent: £31m, received: £65.4m) 13. Crystal Palace – Net spend: £0m (spent: £0m, received: £0m) 11. Swansea City – Net spend: £8.5m (spent: £11m, received: £2.5m) 19. Burnley – Net spend: -£28m (spent: £2m, received: £30m) 20 20 20 20 16. Southampton – Net spend: -£7.2m (spent: £5m, received: £12.2m) 9. Watford – Net spend: £16m (spent: £16m, received: £0m) 20 2. Manchester City – Net spend: £58.3m (spent: £78.3m, received: £20m) 20 12. Newcastle – Net spend: £4.1m (spent: £14.9m, received: £10.8m) 20 20 17. West Ham – Net spend: -£8m (spent: £0m, received: £8m) 14. Everton – Net spend: -£1.3m (spent: £91.9m, received: £93.2m) 20 4. Liverpool – Net spend: £38m (spent: £39.9m, received: £1.9m) This summer’s transfer window looks set to break all manner of records.So far Premier League clubs have spent £571million making it the fifth biggest window on record – and there’s still 50 days to go.But, which club has splashed the most cash in this window according to net transfer spend?Scroll through the gallery above to see who the league’s biggest spenders are this summer.Figures from Sporting Intelligence correct as of 10/7/17. 3. Arsenal – Net spend: £50.7m (spent: £52.7m, received: £2m) 6. Bournemouth – Net spend: £30m (spent: £30m, received: £0m) 20 20 7. Leicester City – Net spend: £27.6m (spent: £27.6m, received: £0m) last_img read more

Most patients who underwent transcatheter valve replacement experience prosthesispatient mismatch

first_imgReviewed by James Ives, M.Psych. (Editor)Sep 24 2018In the largest multi-institutional study to date, led by researchers from Penn Medicine, the team found that among patients who underwent a transcatheter aortic valve replacement (TAVR), a high number experienced severe and moderate cases of prosthesis-patient mismatch (PPM)–meaning the implanted heart valve is too small for the patient which can lead to inadequate blood flow. The team also found that the risk of death and of heart failure readmissions were 19 percent and 12 percent higher, respectively, after one year as compared to patients without severe PPM.Results of the study were presented today as a late-breaking abstract at the Transcatheter Cardiovascular Therapeutics (TCT) 2018 meeting in San Diego and simultaneously published online in the Journal of the American College of Cardiology.”This is an important contemporary snapshot of what’s happening in the real world with commercial TAVR procedures,” said the study’s lead author Howard C. Herrmann, MD, FACC, MSCAI, the John W. Bryfogle Professor of Cardiovascular Medicine and Surgery at Penn’s Perelman School of Medicine and director of Penn Medicine’s Interventional Cardiology Program, who presented the results at TCT. “This is the first study that is large enough to demonstrate meaningful data associated with PPM for a relatively new procedure like TAVR. Based on these findings, PPM is an important problem in this population, one that deserves greater awareness among operators. And being aware of it is the first step in trying to prevent it.”TAVR was approved by the Food and Drug Administration in 2011 for the treatment of aortic stenosis, a narrowing of the heart’s aortic valve, and has revolutionized valve replacement options for patients with this disease who are too sick or too high risk for surgical (open-heart) valve replacement (SAVR). This minimally invasive, catheter-based approach allows physicians to replace the aortic valve without need to remove the old, damaged one.Of the 62,125 patients who received TAVRs in the United States between 2014 and 2017 and who were evaluated, researchers found 12 percent experienced severe PPM, while 25 percent had moderate PPM. Researchers collected and analyzed patient data from the U.S. STS/ACC Transcatheter Valve Therapy (TVT) Registry, which tracks all commercial procedures performed in the United States. To further study patient outcomes, the authors linked patients in the U.S. STS/ACC TVT registry to Centers for Medicare & Medicaid Services’ administrative claims data for 37,470 of their patients. After 30 days, patients with severe PPM had higher rates of heart failure hospitalization, stroke, and death.Related StoriesRepurposing a heart drug could increase survival rate of children with ependymomaDiet and physical exercise do not reduce risk of gestational diabetesBariatric surgery should be offered to all patients who would benefitHistorically, PPM has been associated with worse outcomes after SAVR, however, less has been known about the incidence, outcomes, and predictors of PPM in TAVR patients. Past studies have been small, with limited follow up, and some from single centers–combined, they only represent 4,000 patients–and measurement techniques for the valve opening have been inconsistent.PPM is a mismatch of the blood flow dynamics of the prosthetic valve and the amount of blood the heart needs to pump to the rest of the patient’s body. For example, having too small of a valve in a person with a large body surface area (height and weight) affects their ability to get enough blood flow when they exercise. In previous studies, severe PPM in both SAVR and TAVR patients have been associated with higher risk of death and hospital readmission, decreased exercise abilities, and a higher rate of valve deterioration over time.The authors identified several predictors of PPM, including patients with a smaller valve prosthesis, those who had a larger body surface area, or patients who are female or younger.”Severe PPM occurs frequently after TAVR procedures, and it results in worse outcomes, even after a short period of one year,” Herrmann said. “Now that we’re more aware of this, we need to look at strategies and compare devices and techniques in future studies to determine what will help us best limit this risk or avoid it in the future.”Source: read more